ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle
Our study uncovers the significant role of ArfGAP3 in enhancing differentiation capacity and mitochondrial function through mediating Rab5a expression to activate IRS1-AKT-mTOR signalling pathways and promote autophagy during the ageing process. These findings underscore the potential of ArfGAP3 as a promising therapeutic target for ameliorating the decline in skeletal muscle function associated with ageing.
Authors
- Ya Xiao
- Fangyi Zhu
- Su‐Ting T. Li (ORCID: https://orcid.org/0000-0002-9104-912X)
- Xiaoyu Huang (ORCID: https://orcid.org/0000-0002-9781-972X)
- Wenyi Jin (ORCID: https://orcid.org/0000-0002-3226-1606)
- Bingshu Li (ORCID: https://orcid.org/0000-0001-8276-0449)
- Shufei Zhang (ORCID: https://orcid.org/0000-0002-4614-4718)
- Yang Li (ORCID: https://orcid.org/0000-0001-9612-2704)
- Hong Li (ORCID: https://orcid.org/0000-0002-3841-5557)
- Liying Chen (ORCID: https://orcid.org/0000-0003-0990-7648)
- Chen Mao (ORCID: https://orcid.org/0000-0002-6537-6215)
- Jie Min (ORCID: https://orcid.org/0000-0002-6674-3339)
- Jianming Tang (ORCID: https://orcid.org/0000-0003-0230-9880)
- Lian Yang (ORCID: https://orcid.org/0000-0003-4664-2474)
- Shasha Hong
- Yubiao Zhang
Institutions
- City University of Hong Kong (HK)
- Wuhan University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13725
- Citations
- 4
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China