Impact of tadalafil on cardiovascular and organ dysfunction induced by experimental sepsis
Tadalafil improved microcirculation of septic animals; however, no beneficial effects were observed on macrocirculation and inflammation parameters. Then, the potential benefit of tadalafil in the prognosis of sepsis should be evaluated within a therapeutic strategy covering all sepsis injury mechanisms.
Authors
- Gustavo Ferreira Alves (ORCID: https://orcid.org/0000-0003-2529-2006)
- Lucas Braga Albino (ORCID: https://orcid.org/0000-0003-1800-1792)
- Daniel Fernandes (ORCID: https://orcid.org/0000-0002-8935-4176)
- Gabrielle Delfrate (ORCID: https://orcid.org/0000-0002-4326-9566)
- Junior Garcia Oliveira
- Marcelo Almeida Nakashima
Institutions
- Universidade Federal de Santa Catarina (BR)
Publication Details
- Journal
- Acute and Critical Care
- Published
- 2025-02-18
- DOI
- https://doi.org/10.4266/acc.002904
- Citations
- 2
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Universidade Federal de Santa Catarina