Tumor Treating Fields therapy in platinum-resistant ovarian cancer: Results of the ENGOT-ov50/GOG-3029/INNOVATE-3 pivotal phase 3 randomized study

No new safety signals were identified. TTFields+PTX did not significantly improve OS compared with PTX in the intent-to-treat population. An exploratory post-hoc analysis suggests a potentially favorable benefit-risk profile for TTFields therapy in PLD-naive patients.

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Institutions

Publication Details

Journal
European Journal of Cancer
Published
2025-02-18
DOI
https://doi.org/10.1016/j.ejca.2025.115306
Citations
7
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
11.89

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article

Tumor Treating Fields therapy in platinum-resistant ovarian cancer: Results of the ENGOT-ov50/GOG-3029/INNOVATE-3 pivotal phase 3 randomized study

Jalid Sehouli, Antonio González-Martı́n, Hannelore Denys, Radosław Mądry et al.
7 citations
European Journal of Cancer
Ovarian cancer diagnosis and treatment
11.89
article

Tumor Treating Fields therapy in platinum-resistant ovarian cancer: Results of the ENGOT-ov50/GOG-3029/INNOVATE-3 pivotal phase 3 randomized study

Jalid Sehouli, Antonio González-Martı́n, Hannelore Denys, Radosław Mądry, Bradley J. Monk, David M. O’Malley, Premal H. Thaker, Susie Lau, Giovanni Scambia, Jayanthi Lea, Andrea Bagaméri, Luís Manso, Sabrina Chiara Cecere, Jacob Korach, Martin Hruda, Antonio Ardizzoia, Annouschka Laenen, Viola A Heinzelmann-Schwarz, Ignace Vergote, Larry J. Copeland, Jessica Thomes Pepin, Regina Berger, David A. Iglesias, David Cibula, Joseph Buscema, Ayelet Shai, Stéphanie Henry, Toon Van Gorp, Vanda Salutari, Nicoletta Colombo
article en
7 citations

Abstract

No new safety signals were identified. TTFields+PTX did not significantly improve OS compared with PTX in the intent-to-treat population. An exploratory post-hoc analysis suggests a potentially favorable benefit-risk profile for TTFields therapy in PLD-naive patients.

European Journal of CancerVol. 219
Poznan University of Medical Sciences (PL), University of St. Thomas - Minnesota (US), Washington University in St. Louis (US), Charles University (CZ), Sheba Medical Center (IL), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), Ghent University Hospital (BE), Rambam Health Care Campus (IL), Jewish General Hospital (CA), University Hospital of Basel (CH), Agostino Gemelli University Polyclinic (IT), University of Florida (US), The European Academy of Gynaecological Surgery (BE), CHU Dinant Godinne UCL Namur (BE), Southwestern Medical Center (US), Hospital Universitario 12 De Octubre (ES), Alessandro Manzoni Hospital (IT), Florida Cancer Specialists & Research Institute (US), National Institute of Oncology (HU), Tirol Kliniken (AT), Tumour Institute of Tuscany (IT), Clinica Universidad de Navarra (ES), University Hospital Kralovske Vinohrady (CZ), General University Hospital in Prague (CZ), Arizona Oncology (US), The Ohio State University (US), European Institute of Oncology (IT), Charité - Universitätsmedizin Berlin (DE), The University of Texas Southwestern Medical Center (US), UCLouvain (BE), KU Leuven (BE)
Amgen, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Gilead Sciences, Teva Pharmaceutical Industries, F. Hoffmann-La Roche, Ludwig Institute for Cancer Research, Regeneron Pharmaceuticals, Intuitive Surgical, Exelixis, Jazz Pharmaceuticals, Novocure, Clovis Oncology, Mersana Therapeutics, Incyte, Tarveda Therapeutics, Seagen, Eisai, Swedish Orphan Biovitrum, PharmaMar, Genentech, EMD Serono, MSD Italia
Good health and well-being, Zero hunger
Openalex Percentile: Top 2%
Ovarian cancer diagnosis and treatment
11.89
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