In vitro activity of aztreonam in combination with relebactam against gram-negative pathogens producing various serine and metallo-β-lactamases
The addition of relebactam has a potential to restore the activity of aztreonam against strains that produce metallo-β-lactamase and serine‑β-lactamase. The combination may have a role in the treatment of infections due to these strains in countries without access to ceftazidime-avibactam.
Authors
- Yohei Doi (ORCID: https://orcid.org/0000-0002-9620-2525)
- Yasufumi Matsumura (ORCID: https://orcid.org/0000-0001-8595-8944)
- Kazuaki Matsumoto (ORCID: https://orcid.org/0000-0002-5462-1684)
- Masahiro Suzuki (ORCID: https://orcid.org/0000-0003-4550-3499)
- Sho Saito
- Yoshikazu Ishii
- Kengo Hayashi (ORCID: https://orcid.org/0000-0001-7098-1228)
Institutions
- Hiroshima University (JP)
- Fujita Health University (JP)
- Keio University (JP)
- Kyoto University (JP)
- National Center for Global Health and Medicine (JP)
- Planetary Systems (United States) (US)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-02-18
- DOI
- https://doi.org/10.1016/j.jgar.2025.02.008
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Center for Global Health and Medicine