Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease
This study provides a novel mechanism underlying the liver-bone crosstalk, demonstrating that circSOD2 upregulation in hepatocytes, induced by oxidative stress, inhibits osteogenic differentiation of BMSCs by sponging miR-29b. These findings offer a better understanding of the relationship between MAFLD and osteoporosis.
Authors
- Yi Zhu (ORCID: https://orcid.org/0000-0002-7689-4931)
- Mugahed Abdullah Hasan Albahde
- Hongyu Zhang (ORCID: https://orcid.org/0009-0003-9600-3504)
- Meng Luo (ORCID: https://orcid.org/0000-0002-2928-8277)
- LI Liang-ping (ORCID: https://orcid.org/0000-0001-8102-7851)
- Minjie Xie (ORCID: https://orcid.org/0000-0001-7317-3066)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0002-6817-1813)
- Yongjian Li (ORCID: https://orcid.org/0000-0003-3606-8245)
- Jian-Ying Lou
- Hongbo Liu (ORCID: https://orcid.org/0009-0008-7233-5885)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3748/wjg.v31.i9.98027
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81