Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation
Our findings suggested that RCNSP ameliorated constipation through a dual mechanism: It stimulated colonic MUC2 secretion by activating NLRP6 inflammasome-mediated autophagy and modulated the composition of the mucosal microbiota.
Authors
- Yuebo Jia (ORCID: https://orcid.org/0000-0002-7419-9214)
- Chenheng Wu
- Jianghong Ling (ORCID: https://orcid.org/0000-0001-7550-9694)
- Yeliya Yeertai
- Xuan Yao (ORCID: https://orcid.org/0009-0003-2336-5045)
- Xuejiao Liu (ORCID: https://orcid.org/0009-0005-7045-6323)
- Xiangxiang Wang (ORCID: https://orcid.org/0000-0002-8031-9657)
- Keming Yang
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2025-02-18
- DOI
- https://doi.org/10.3748/wjg.v31.i9.102256
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81