INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associat
In-ICU PCR for pathogens resulted in improved antibiotic stewardship. However, non-inferiority was not demonstrated for cure of pneumonia at 14 days. Further research should focus on clinical effectiveness studies to elucidate whether antibiotic stewardship gains achieved by rapid PCR can be safely and advantageously implemented.
Authors
- Georgia Bercades (ORCID: https://orcid.org/0000-0002-5961-3149)
- Pooja Patel (ORCID: https://orcid.org/0000-0002-7092-8838)
- Kerry Dresser (ORCID: https://orcid.org/0000-0001-7891-8047)
- Virve I. Enne (ORCID: https://orcid.org/0000-0002-0250-6377)
- Giovanni Pipi
- Susan Stirling (ORCID: https://orcid.org/0000-0001-6663-7846)
- Lauran O’Neill (ORCID: https://orcid.org/0000-0003-1099-024X)
- André Charlett (ORCID: https://orcid.org/0000-0001-7154-0432)
- Nigel Klein
- Laura Shallcross (ORCID: https://orcid.org/0000-0003-1713-2555)
- A. John Simpson (ORCID: https://orcid.org/0000-0003-4731-7294)
- Karen Reid
- Giovanni Satta (ORCID: https://orcid.org/0000-0002-0120-7885)
- Matthew Dryden (ORCID: https://orcid.org/0000-0002-8967-169X)
- Paul Aveyard (ORCID: https://orcid.org/0000-0002-1802-4217)
- Deborah Smyth
- Penny Vicary
- P. J. Riley
- R.G. Masterton
- Ian Turner-Bone
- Angela Aramburo (ORCID: https://orcid.org/0000-0002-2521-3550)
- Rhian Bull
- Daniel E. Martin (ORCID: https://orcid.org/0000-0003-0083-6724)
- Rosy Reynolds (ORCID: https://orcid.org/0000-0003-4643-9556)
- Vanya Gant (ORCID: https://orcid.org/0000-0001-6985-4969)
- Catherine L. Saunders (ORCID: https://orcid.org/0000-0002-3127-3218)
- Minnie Gellamucho
- Rob Simpson (ORCID: https://orcid.org/0000-0002-6048-206X)
- Adam P. Wagner (ORCID: https://orcid.org/0000-0002-9101-3477)
- Paul M Dark (ORCID: https://orcid.org/0000-0003-3309-0164)
- Julian Sonksen
- Charlotte Russell (ORCID: https://orcid.org/0000-0002-8194-8033)
- Jenny Tan (ORCID: https://orcid.org/0000-0002-8370-9757)
- Suveer Singh (ORCID: https://orcid.org/0000-0003-3219-8966)
- Justin O’Grady (ORCID: https://orcid.org/0000-0001-5412-7152)
- Luke S. P. Moore (ORCID: https://orcid.org/0000-0001-7095-7922)
- Mark Peters (ORCID: https://orcid.org/0000-0003-3653-4808)
- Patrick Thompson (ORCID: https://orcid.org/0000-0002-3734-4160)
- Julie Barber (ORCID: https://orcid.org/0000-0001-5762-762X)
- Robert Horne (ORCID: https://orcid.org/0000-0002-3068-8438)
- Martin Llewelyn (ORCID: https://orcid.org/0000-0002-6811-1124)
- Justin Z. Wang (ORCID: https://orcid.org/0000-0001-8998-7443)
- David Brealey (ORCID: https://orcid.org/0000-0002-1982-3379)
- Helen Winmill
- David Shaw
- Juliet High (ORCID: https://orcid.org/0000-0003-2555-2349)
- Ingrid Hass
- J. Cassidy
- Zaneeta Dhesi (ORCID: https://orcid.org/0000-0003-2495-1356)
- Amander Wellings
- David M. Livermore (ORCID: https://orcid.org/0000-0002-9856-3703)
- Sarah-Jane Stewart (ORCID: https://orcid.org/0000-0003-2396-9028)
- Nabeela Mughal (ORCID: https://orcid.org/0000-0001-8013-5412)
- Elizabeth Cooper (ORCID: https://orcid.org/0000-0001-8993-7067)
- Paulo Costa (ORCID: https://orcid.org/0000-0002-7550-8285)
- Jaime Carungcong
- Carly Tooke
- Victoria Waugh
- Alyssa M. Pandolfo (ORCID: https://orcid.org/0000-0003-0455-496X)
- Margaret McWilliams (ORCID: https://orcid.org/0000-0003-0840-9970)
- Ingeborg Welters (ORCID: https://orcid.org/0000-0002-3408-8798)
- Ann Marie Swart (ORCID: https://orcid.org/0000-0002-9359-6995)
- Valérie Page (ORCID: https://orcid.org/0000-0002-1506-2533)
- Susan Bennett
- Federico Ricciardi (ORCID: https://orcid.org/0000-0002-4473-7691)
- Robert Parker (ORCID: https://orcid.org/0000-0003-1910-8081)
- Sara Mingo
- Jeronimo Cuesta
- Laura Tous
- Nehal Patel (ORCID: https://orcid.org/0000-0002-6054-7185)
- David Turner (ORCID: https://orcid.org/0000-0002-1689-4147)
- Helder Filipe (ORCID: https://orcid.org/0000-0002-6202-7685)
- Laura Wilding
- Xiaobei Zhao
- Antony Colles (ORCID: https://orcid.org/0000-0002-2268-0903)
- Karen Williams
- Rebecca Harmston
- Kamal Liyanage
- Julie North
- Hala Kandil
- Benny P. Cherian (ORCID: https://orcid.org/0000-0001-7107-9869)
- Naseem Ahmed (ORCID: https://orcid.org/0009-0007-7264-7339)
- David Mack
- Mark de Neef
- Philip Milner
- Jennie Griffiths
- Eleanor Tudtud
- Zoran Aman
- Olugbenga Akinugbe
- Michael Karlikowski
Institutions
- University of East Anglia (GB)
- University College Hospital (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Liverpool (GB)
- Royal Free London NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- University Hospitals of North Midlands NHS Trust (GB)
- West Hertfordshire Hospitals NHS Trust (GB)
- The Royal Free Hospital (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Royal London Hospital (GB)
- Royal Liverpool University Hospital (GB)
- Hampshire Hospitals NHS Foundation Trust (GB)
- Aintree University Hospital (GB)
- Portsmouth Hospitals NHS Trust (GB)
- Birmingham Children's Hospital (GB)
- UCL Biomedical Research Centre (GB)
- Bupa Cromwell Hospital (GB)
- University College London (GB)
- University of Plymouth (GB)
Publication Details
- Journal
- Intensive Care Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1007/s00134-024-07772-2
- Citations
- 30
- Primary Topic
- Nosocomial Infections in ICU
- Type
- article
- Field-Weighted Citation Impact
- 46.36
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- Imperial College London
- University College London
- National Chiao Tung University
- University College London Hospitals NHS Foundation Trust
- Programme Grants for Applied Research
- UCLH Biomedical Research Centre
- NIHR Imperial Biomedical Research Centre