Preparation of a Nanodiamond Suspension with Immobilized Scandium Isotopes for in vivo Studies
Abstract Conditions were determined for preparing a suspension of detonation synthesis nanodiamonds (NDs) with immobilized scandium in solutions, meeting the requirements to solutions for intravenous administration of radiopharmaceuticals based on the medicinal isotopes 44 Sc and 47 Sc. The possibility of the quantitative binding of scandium with ND samples in isotonic solutions having the required pH and containing the minimal ND amount was demonstrated. The Freundlich and Langmuir adsorption isotherm parameters and Δ G of adsorption were determined for the most promising ND sample under the optimum conditions. The conditions found for preparing NDs with immobilized scandium isotopes will allow in vivo studies in the future.
Authors
- Elena S. Odintsova (ORCID: https://orcid.org/0000-0002-4098-5559)
- Boris F. Myasoedov (ORCID: https://orcid.org/0000-0002-1400-0314)
- Е. А. Нестеров (ORCID: https://orcid.org/0000-0001-9138-6700)
- С. Е. Винокуров (ORCID: https://orcid.org/0000-0002-1384-1066)
- A. G. Kazakov (ORCID: https://orcid.org/0000-0003-4872-9792)
- I.A. Ushakov (ORCID: https://orcid.org/0000-0002-3821-5176)
- В. С. Скуридин (ORCID: https://orcid.org/0000-0002-1300-1980)
- Daria V. Pavlova
Institutions
- Russian Academy of Sciences (RU)
- D. Mendeleyev University of Chemical Technology of Russia (RU)
- National Research Tomsk State University (RU)
- Tomsk Polytechnic University (RU)
- Progamme National Contre le Tuberculose (BJ)
- V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry (RU)
- Russian Academy of Natural Sciences (RU)
Publication Details
- Journal
- Radiochemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1066362224060110
- Primary Topic
- Diamond and Carbon-based Materials Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00