The Use of the Macromolecule Products of the Biogenic Reaction as the Basic Nucleus in the Preparation of Quinazoline Derivatives

Abstract In light of the medical significance of quinazoline derivatives, this study focuses on the synthesis of new quinazoline derivatives derived from the reaction of hydrazones with amino benzoic acid. Ethyl 6‐methyl‐2‐oxo‐4‐phenyl‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate, obtained via the Biginelli reaction, serves as a nucleophile in the preparation of hydrazides. Subsequently, these hydrazides react with various benzaldehyde derivatives to form hydrazones. The synthesized compounds are characterized using physical and spectroscopic techniques including melting point determination, NMR spectroscopy ( 1 H‐NMR and 13 C‐NMR), and FTIR spectroscopy to confirm their chemical structure. The biological activity of these compounds is evaluated against two bacterial strains, Escherichia coli and Staphylococcus aureus , to assess their potential application in antimicrobial therapy.