Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials
The current results support including EOAD patients in longitudinal clinical trials, and generate evidence of validation for using 12-month reliable cognitive change as a clinical outcome metric in clinical trials in EOAD cohorts like LEADS. Doing so will enhance the success of EOAD trials and permit a better understanding of individual responses to treatment.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Stephen Salloway (ORCID: https://orcid.org/0000-0002-2631-0942)
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Alexander Taurone
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kyle Womack (ORCID: https://orcid.org/0000-0002-6060-9075)
- Sharon J. Sha (ORCID: https://orcid.org/0000-0002-3666-1463)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Ranjan Duara (ORCID: https://orcid.org/0000-0001-8060-6309)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- David Clark (ORCID: https://orcid.org/0000-0002-8882-9205)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Paul Aisen
- Neill R. Graff‐Radford
- Kala Kirby
- Liana G. Apostolova
- Maryanne Thangarajah
- Meghan Riddle
- Jane Musema
Institutions
- Northwestern University (US)
- Alzheimer's Association (US)
- Mayo Clinic (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Banner Health (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Southern States University (US)
- Stanford University (US)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100075
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Alzheimer's Association
- National Institutes of Health
- National Institute on Aging