Antiaging Synergistic Effect of Vitamins C, A, and E Topical Organogel Formulation: Clinical and ex vivo Assessments Results

The aging process is modulated by both endogenous and exogenous factors, which can lead to the degradation of collagen and elastin, resulting in wrinkles, skin laxity, and alterations in skin texture. Age-related declines in melanin production contribute to irregular pigmentation and an elevated susceptibility to ultraviolet damage. Topical applications of vitamins, notably C, A, and E, are crucial in mitigating skin aging and enhancing dermal health. These vitamins act as antioxidants, protecting against oxidative damage, inhibiting melanogenesis, lowering melanin concentrations, and facilitating skin regeneration. Nevertheless, the stability of these vitamins within cosmetic formulations poses a considerable challenge, particularly vitamin C, whose instability may compromise the efficacy of topical preparations. T