Eosinophilic Fasciitis Following COVID-19 Vaccination

A 60-year-old female developed symptoms of eosinophilic fasciitis 10 days after receiving the second dose of the COVID-19 vaccine, characterized by sclerotic and hyperpigmented lesions, hypereosinophilia, and positive antinuclear antibodies. The diagnosis was confirmed through deep skin biopsy and MRI, and treatment with prednisone and methotrexate showed great improvement. This case highlights the potential for eosinophilic fasciitis to be triggered by the COVID-19 vaccine, although the exact mechanisms and relationship remain unclear