Comparative Phase Solubility Analysis of Olanzapine by 24 Optimization Techniques with Different Water-Soluble Carriers

Background The solubility of medications significantly affects their absorption and therapeutic effectiveness. Drugs with poor solubility often faces challenges in formulation development leading to low bioavailability and fluctuations in blood concentration. Olanzapine, an atypical antipsychotic drug used in treating schizophrenia, exemplifies this issue with its low water solubility and subsequent low bioavailability. Materials and Methods This study explores the enhancement of olanzapine