Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/<scp>GPX4</scp> Signaling Pathway
The AST effectively inhibits neuronal ferroptosis in both in vivo and in vitro epilepsy models via the Nrf2/GPX4 pathway. This finding suggests that AST holds promise as a potential therapeutic agent for the treatment of epilepsy.
Authors
- Qichang Liu (ORCID: https://orcid.org/0009-0007-5681-4045)
- Shihao Chen (ORCID: https://orcid.org/0000-0001-5913-3236)
- Linqian Zhao
- Yuqing Xiao (ORCID: https://orcid.org/0009-0001-0164-8234)
- Xing Jin (ORCID: https://orcid.org/0009-0009-5398-369X)
- Huiqin Xu
Institutions
- Zhejiang Chinese Medical University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70238
- Citations
- 13
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 19.74