Tau <scp>PET</scp> Imaging With [<sup>18</sup><scp>F</scp>]<scp>MK</scp>‐6240: Limited Affinity for Primary Tauopathies and High Specificity for Alzheimer's Disease
[<sup>18</sup>F]MK-6240 tau-PET has a special affinity for tauopathies involving 3R/4R paired helical filaments: AD, PART (Aβ- subjects with MTL-restricted tau-PET signal) and some forms of FTD while most primary tauopathies do not exhibit significant cortical signal. Positive neocortical scans are therefore highly specific for AD tauopathy. Based on those and previous results, we propose a diagnostic flowchart for MCI subjects suspected of AD or another tauopathy which may significantly reduce the need for amyloid PET or CSF measurement.
Authors
- Lara Huyghe (ORCID: https://orcid.org/0009-0009-3568-3474)
- Renaud Lhommel (ORCID: https://orcid.org/0000-0003-0668-6122)
- Adrian Ivanoiu
- Thomas Gérard (ORCID: https://orcid.org/0000-0001-7997-3945)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Lisa Quenon (ORCID: https://orcid.org/0000-0001-9139-2422)
- Yasmine Salman (ORCID: https://orcid.org/0000-0002-8564-5136)
- Laurence Dricot (ORCID: https://orcid.org/0000-0002-8613-2420)
- Lise Colmant (ORCID: https://orcid.org/0009-0006-6511-0819)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
- Emilien Boyer (ORCID: https://orcid.org/0009-0009-6222-4580)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Harvard University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- UCLouvain (BE)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/ene.70068
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Fonds De La Recherche Scientifique - FNRS
- Walloon excellence in life sciences and biotechnology