Hypotension after anesthesia induction in patients taking tricyclic antidepressants—A case series

Monosymptomatic perioperative hypotension without a significant increase in serum tryptase can be caused by TCAs and this is an important differential diagnosis to anaphylaxis. In patients on regular treatment with TCA perioperative hypotension responds well to noradrenaline or adrenaline but less well to vasopressors such as phenylephrine and ephedrine used perioperatively.