Role of Curcumin and Fenofibrate on Cardiovascular Events in Type 2 Diabetes Mellitus.

Background and aim Type 2 diabetes mellitus is associated with cardiovascular complications that account for a high percentage of mortality and increase the clinical burden on the healthcare system. Herbal products like curcumin and chemical drugs like fenofibrate were found to be effective in decreasing complications associated with heart in type 2 diabetes. The aim of this study is to evaluate the role of curcumin and fenofibrate on cardiovascular complications in type 2 diabetes in a minireview.Methods We reviewed the online databases PubMed, Science Direct, and Google Scholar for articles discussing the impact of curcumin or fenofibrate in improving lipid profile in patients with type 2 diabetes. Results The prior studies demonstrated the impact of consuming curcumin or fenofibrate to improve the lipid profile in people with type 2 diabetes. Triglycerides (TG), low-density lipoprotein (LDL), and total cholesterol (TC) were reduced with either curcumin or fenofibrate. In contrast, high-density lipoprotein (HDL) levels were increased. Conclusions Curcumin or fenofibrate consumption in patients with type 2 diabetes enhances lipid profile, hence decreasing insulin resistance and reducing cardiovascular complications.