Forkhead Box p3 Gene Polymorphism in Bronchial Asthma Patients at Aswan University

Background: The lungs are impacted by diverse chronic illnesses such as asthma. Through genetic polymorphisms and epigenetic pathways, the aetiology of asthma may be connected to the changed activities of the forkhead box P3 gene (FOXP3). Objective: the aim of this research was to find whether there was any association between FOXP3 polymorphism rs2232365 and asthma and to study the effect of this polymorphism on asthma severity. Methodology: this research is a case control study of 240 Egyptian participants enlisted and divided into two groups: 120 people with asthma and 120 people were not asthmatic. Results: There was a statistically significant reduction in spirometry parameters (FVC%, FEV1%, and FEV1/FVC ratio) in the patient group relative to the control group. The serum IGE and eosinophils count were higher in cases. A statistically significant difference was observed in the various genotypes of FOXP3 polymorphism (rs2232365) and the most common genotype among the patients under investigation was the GG genotype and it was associated with higher IgE and Eosinophils (both in blood and sputum) in comparison to the AA and AG genotypes (p <0.05).Conclusion: Since the GG Genotype was the most common genotype among the patients under investigation and it was associated with higher IgE and Eosinophil (both in blood and sputum). The GG genotype of rs2232365 may act as a risk allele for bronchial asthma