Regenerative Gynecological Procedures and their Impact on Female Sexual Health and Quality of Sexual Life: A Longitudinal Pilot Study

Background: Female sexual dysfunction (FSD) is a prevalent condition often associated with physiological changes, negatively impacting women's quality of life (QoSL). Regenerative gynecological procedures offer potential solutions, yet their impact on sexual health and QoSL requires further investigation. Aim: This study aimed to comprehensively assess the effects of various regenerative gynecological procedures on female sexual health and QoSL.Methods: A longitudinal pilot study was conducted, enrolling 64 sexually active women who underwent regenerative procedures (e.g., platelet-rich plasma [PRP], hyaluronic acid [HA], fat grafting, stem cells, exosomes, polydeoxyribonucleotide [PDRN], and acellular matrices). The validated Female Sexual Quality of Life (SQOL-f) questionnaire was administered at baseline and 6 months pos-intervention, along with a detailed assessment of specific sexual function domains.Results: Participants (mean age 39.9 years) commonly reported vaginal laxity, incontinence, and various sexual difficulties at baseline. Post-intervention, significant improvements were observed in multiple domains, including sexual selfesteem, desire, arousal, lubrication, orgasm, satisfaction, and overall QoSL. Confidence as a sexual partner, worry about sexual life, avoidance of intercourse, and satisfaction with sexual frequency also improved significantly. However, minimal changes were observed in closeness to partner and communication about sexual matters.Conclusion: Regenerative gynecological procedures demonstrate a promising potential for enhancing female sexual health and QoL, with significant improvements across multiple domains of sexual function. However, addressing broader relational and psychological aspects may require additional interventions. Further research, including randomized controlled trials, is necessary to validate these findings and establish comprehensive treatment guidelines