Radiographic evaluation to assess bone density upon administration of Low-Intensity 660 nm Laser Therapy alongside Nano-hydroxyapatite and antioxidant compounds (N-acetylcysteine) for Dental Socket Preservation Following Extraction Utilizing CBCT

Purpose: To assess the preservation of bone density upon tooth extraction utilising low-level laser therapy together with nano-hydroxyapatite and antioxidant substance (N-acetylcysteine). Materials and Methods: The study sample comprised 30 randomly selected patients, evenly distributed across three groups. Group I, the socket was sealed by an absorbable collagen membrane without graft materials following tooth extraction. In Group II, a combination of nano-hydroxyapatite and antioxidant agents (N-acetylcysteine) was introduced into the empty socket, followed by placing a bioabsorbable collagenous membrane over the grafting material, then sutured. Group III, the same mixture of nano-hydroxyapatite and antioxidant agents was applied to the extracted socket, followed by the adaptation of an absorbable collagen membrane over the graft and suturing, in addition to low-level 660 nm laser therapy (LLLT) administered three times weekly for two weeks, power of 25 mW, and duration of 120 seconds. Bone density at the extraction site was evaluated using cone beam computed tomography (CBCT). and the added bone graft. Bone density was measured immediately and at three and six months postoperatively. Results: The NHA and NAC groups subjected to LLLT exhibited the most significant improvement in bone density measurements compared to the other groups. Conclusions: a combination of NHA and antioxidant agents (N-acetylcysteine), along with the application of LLLT to alveolar socket post-extraction, minimised bone resorption after six months from grafting that can be safely utilised for socket maintenance. Keywords: LLLT, bone healing, NHA, NAC