Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p
These findings suggest that KPNA2 is a key gene that promotes BCa progression, can potentially be a novel tumor marker, and may serve as a new therapeutic target for BCa.
Authors
- Cong Yin (ORCID: https://orcid.org/0000-0001-6334-4677)
- Yao Lin (ORCID: https://orcid.org/0000-0002-0493-0155)
- Shuai Ye
- Cen Liufu (ORCID: https://orcid.org/0009-0009-4479-8695)
- Yan Wang (ORCID: https://orcid.org/0000-0002-5695-7907)
- Liqun Zhou (ORCID: https://orcid.org/0000-0003-2795-9038)
- Tao Zhu (ORCID: https://orcid.org/0000-0001-7688-8104)
- Jiahao Jiang (ORCID: https://orcid.org/0000-0002-9164-8843)
- Mingxia Wang (ORCID: https://orcid.org/0000-0003-2340-8941)
- Bentao Shi (ORCID: https://orcid.org/0000-0003-3185-1740)
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- Peking University First Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen University Health Science Center (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- China Population and Development Research Center (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1186/s11658-025-00687-w
- Citations
- 9
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Peking University
- Shenzhen University
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Sanming Project of Medicine in Shenzhen