Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders
Modulation of vascular tone in HCAs and HMMAs by activation of TRPM3 is sex-dependent, likely involving NMDA receptors. This represents a new therapeutic direction, targeting sex dimorphism in migraine and its related cardiovascular events.
Authors
- Dennis J.L.G. Schutter (ORCID: https://orcid.org/0000-0003-0738-1865)
- Arnaud J.P.E. Vincent (ORCID: https://orcid.org/0000-0003-0865-8272)
- Carlos M. Villalón (ORCID: https://orcid.org/0000-0003-4117-1343)
- Antoon van den Bogaerdt
- Usha M. Musterd‐Bhaggoe
- A.H. Jan Danser (ORCID: https://orcid.org/0000-0002-5052-3585)
- Eduardo Rivera‐Mancilla (ORCID: https://orcid.org/0000-0003-4559-4028)
- Antoinette MaassenVanDenBrink (ORCID: https://orcid.org/0000-0001-7176-126X)
Institutions
- Erasmus MC (NL)
- Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (MX)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1111/bph.17472
- Citations
- 5
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Consejo Nacional de Ciencia y Tecnología
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Secretaría de Estado de Ciencia, Tecnología e Innovación