Identification of IL-34 and Slc7al as potential key regulators in MASLD progression through epigenomic profiling
Our study reveals that active enhancers and heterochromatin associated with metabolic and inflammatory genes are extensively reprogrammed in MCD-diet mice, and <i>Il-34</i> and <i>Slc7al</i> are potentially key genes regulating the progression of MASLD.
Authors
- Ziyin Huang
- Min Wu (ORCID: https://orcid.org/0000-0003-1372-4764)
- Yujia Ke
- Liping Yu (ORCID: https://orcid.org/0000-0002-3202-3472)
- Lianyun Li (ORCID: https://orcid.org/0000-0003-4194-3059)
- Huan Li (ORCID: https://orcid.org/0009-0002-8321-2860)
- Ming‐Liang Wei (ORCID: https://orcid.org/0000-0003-3970-979X)
- Chuang Wang (ORCID: https://orcid.org/0000-0002-9157-0417)
- Yong Xiao (ORCID: https://orcid.org/0009-0003-8418-8206)
- Mingkai Chen (ORCID: https://orcid.org/0000-0001-6771-0523)
- Zi‐Qi Mu
- Chuanfei Zeng
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1080/17501911.2025.2467028
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Renmin Hospital of Wuhan University