Loss of <scp>VSTM2A</scp> promotes adipocyte hypertrophy and disrupts metabolic homeostasis
VSTM2A is dispensable for adipose tissue formation, but its loss causes adipocyte hypertrophy and impairs glucose and lipid homeostasis. Our study also underscores a critical role of the lysosome in initiating adipogenesis.
Authors
- Mathilde Mouchiroud (ORCID: https://orcid.org/0000-0002-8879-0988)
- Manal Al Dow
- Mathieu Laplante (ORCID: https://orcid.org/0000-0002-1752-6741)
- William T. Festuccia (ORCID: https://orcid.org/0000-0003-4769-0806)
- Gustavo R. Gilio (ORCID: https://orcid.org/0000-0002-9850-6389)
- Michel Rochette
- Mickaël Massicard
- Venkata Manem (ORCID: https://orcid.org/0000-0003-1427-2819)
- Mathieu C. Morissette (ORCID: https://orcid.org/0000-0003-1371-1429)
- Blandine Secco
- Yves Gélinas (ORCID: https://orcid.org/0009-0003-8961-7532)
- Mark A. Hardy (ORCID: https://orcid.org/0000-0001-6607-0616)
Institutions
- Universidade de São Paulo (BR)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
Publication Details
- Journal
- Obesity
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1002/oby.24224
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Université Laval
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé