H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment
This study demonstrated that elevated H4K12la directly activates the FOXO1 signaling pathway, promoting oxidative stress and contributing to DACD phenotypes.
Authors
- Lulu Song (ORCID: https://orcid.org/0000-0002-9105-2580)
- Liping Yu
- Jinping Zhang (ORCID: https://orcid.org/0000-0001-9223-643X)
- Ying Yang (ORCID: https://orcid.org/0000-0002-3751-2590)
- Bo Zhang (ORCID: https://orcid.org/0009-0006-3586-2382)
Institutions
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1016/j.jare.2025.02.020
- Citations
- 20
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 16.12