Identification and characterization of factor XI autoantibodies in 2 patients with systemic lupus erythematosus: insights into mechanisms of acquired factor XI deficiency
These autoantibodies inhibited FXI function and promoted its clearance. The inhibitors targeted the 2 most important FXIa domains for FIX activation and demonstrated properties similar to those described in patients with FXI alloantibody inhibitors.
Authors
- Jeremy W. Jacobs (ORCID: https://orcid.org/0000-0002-5719-9685)
- David Gailani (ORCID: https://orcid.org/0000-0001-8142-8014)
- Sergey N. Fedorov (ORCID: https://orcid.org/0000-0001-7318-8866)
- Michael Pettit
- Miriam Brown (ORCID: https://orcid.org/0000-0001-5006-7068)
- Priyanka Srivastava (ORCID: https://orcid.org/0000-0003-1840-5711)
- Benjamin F. Tillman (ORCID: https://orcid.org/0000-0001-6282-9322)
- Anton Matafonov
- Amy Zhou (ORCID: https://orcid.org/0000-0003-3259-1995)
- Gail Baxter
- Christine Fuja (ORCID: https://orcid.org/0000-0001-8044-5314)
- Charles S. Eby
Institutions
- Washington University in St. Louis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102703
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- National Institutes of Health
- National Heart, Lung, and Blood Institute