How to use mTOR inhibitors in children

Paediatricians across many specialities and pharmacists are increasingly being asked to prescribe, or jointly look after, children treated with mammalian target of rapamycin (mTOR) inhibitors (eg, sirolimus and everolimus). There is an expanding list of conditions including tuberous sclerosis and vascular malformations where treatment with mTOR inhibitors may help. This brief practice pointer summarises the practical steps before starting these treatments, what potential side effects to discuss with families and what monitoring arrangements should be put in place.

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Publication Details

Journal
Archives of Disease in Childhood Education & Practice
Published
2025-02-16
DOI
https://doi.org/10.1136/archdischild-2024-327852
Citations
1
Primary Topic
Tuberous Sclerosis Complex Research
Type
article
Field-Weighted Citation Impact
1.16
Controls
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article

How to use mTOR inhibitors in children

Yincent Tse, Nicola Vasey, Rhys Huw Thomas, Stephen Owens et al.
1 citations
Archives of Disease in Childhood Education & Practice
Tuberous Sclerosis Complex Research
1.16
article

How to use mTOR inhibitors in children

Yincent Tse, Nicola Vasey, Rhys Huw Thomas, Stephen Owens, Suzy Leech, John Sayer
article en
1 citations

Abstract

Paediatricians across many specialities and pharmacists are increasingly being asked to prescribe, or jointly look after, children treated with mammalian target of rapamycin (mTOR) inhibitors (eg, sirolimus and everolimus). There is an expanding list of conditions including tuberous sclerosis and vascular malformations where treatment with mTOR inhibitors may help. This brief practice pointer summarises the practical steps before starting these treatments, what potential side effects to discuss with families and what monitoring arrangements should be put in place.

Archives of Disease in Childhood Education & PracticeVol. 110(5)
Royal Victoria Infirmary (GB), Newcastle upon Tyne Hospitals NHS Foundation Trust (GB), Newcastle upon Tyne Hospital (GB), NIHR Newcastle Biomedical Research Centre (GB), Great North Children's Hospital (GB), Newcastle University (GB)
Good health and well-being
Openalex Percentile: Top 26%
Tuberous Sclerosis Complex Research
1.16
DOISourceOpenAlex
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How to use mTOR inhibitors in children — Yincent Tse, Nicola Vasey, et al. · Archives of Disease in Childhood Education & Practice (2025) | TGRS Research Map | TGRS