INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE

Prolonged chemotherapy increases side effects that are treated with herbs, such as meniran. Cancer cells have high lipophilicity and Log P corilagin meniran has low bioavailability. The encapsulation of the active ingredient in the reverse micelle system can increase the value of the P log and work selectively. This research aims to determine the effectiveness of the Microemulsion System Reverse Micelle Meniran (MSRMM), a cervical anticancer, in developing herbal medicine. The formulations determine the span of 80 levels that form optimally based on their characterization and effectiveness. The methods included MSRMM making, characterization, and in vitro tests. The results showed that MSRMM F2 (0.50 % span 80) meets optimal requirements, especially droplet size parameters of 2226.4 nm, PDI of 0.2129, and zeta potential of -26.4 mV. MSRMM F2 cervical anticancer IC50 was 171.190 µg/mL and P = 0.047 (P<0.05) compared to meniran extract. In conclusion, MSRMM F2 is the selected formula and has potential as a cervical anticancer herbal drug.