Bioactive nanomotor enabling efficient intestinal barrier penetration for colorectal cancer therapy
Oral drug delivery systems had natural potential for colorectal cancer drug therapy. While the drug delivery efficiency is severely hindered by the complex intestinal barriers, especially mucus and epithelium barriers, resulting in unsatisfactory therapeutic effects and limited clinical translation. In this work, a bioactive self-thermophoretic and gas dual-driven nanomotor is developed for colorectal cancer therapy through efficient intestinal mucus and epithelial barrier penetration. The nanomotor shows intestinal mucus barrier penetration and the paracellular pathway reversibly opening properties of intestinal epithelium barrier, increasing the delivery efficiency of cisplatin by 3.5 folds. Owing to the targeted delivery of cisplatin and the reduced side effects on normal intestinal tissues, the therapeutic efficiency of the nanomotor for colorectal cancer in vivo is as high as 98.6%. With autonomous and reversible intestinal barriers penetration property, the nanoplatform may innovate the current oral drug delivery.
Authors
- Mingzhu Yang (ORCID: https://orcid.org/0000-0002-5484-0836)
- Jinjin Shi (ORCID: https://orcid.org/0000-0003-1531-7265)
- Fengqin Zhao (ORCID: https://orcid.org/0000-0003-1182-6492)
- Junjie Liu (ORCID: https://orcid.org/0000-0002-4096-7959)
- Shuhao Zhang (ORCID: https://orcid.org/0000-0002-0301-5983)
- Zhi‐Hao Wang (ORCID: https://orcid.org/0000-0001-9722-0429)
- Airong Li (ORCID: https://orcid.org/0000-0002-8242-7360)
- Xuejiao Zeng
- Yanbo Yang (ORCID: https://orcid.org/0000-0001-9187-4798)
- Wanting Huang (ORCID: https://orcid.org/0000-0002-2283-4351)
- Hua Liu (ORCID: https://orcid.org/0009-0009-1266-3585)
- Zhenzhong Zhang
Institutions
- Ministry of Education (NZ)
- Ministry of Education of the People's Republic of China (CN)
- Chinese Center For Disease Control and Prevention (CN)
- Zhengzhou University of Light Industry (CN)
- North Central Cancer Treatment Group (US)
- Zhengzhou University (CN)
- Zhengzhou Institute of Machinery (CN)
- Zhengzhou Business University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1038/s41467-025-57045-9
- Citations
- 41
- Primary Topic
- Micro and Nano Robotics
- Type
- article
- Field-Weighted Citation Impact
- 51.58
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhengzhou University