Characterization of nano encapsulated cinnamon bark extract (Cinnamomum burmannii) based on chitosan alginate as a potential drug delivery system for cervical cancer therapy

Objective: This study aims to evaluate the nanoencapsulation potential of cinnamon extract based on the results of characterization tests. Method: Formulation F2 using a combination of 1% chitosan and 1.5% alginate showed optimal characterization results compared to F1 and F3. Results: The results showed that formulation F2 had a particle size of 246.3 nm, PDI of 0.396, and zeta potential of -33.8 mV indicating good physical stability, homogeneous particle distribution, and suitable particle size for nanoencapsulation applications. In addition, particle visualization showed clear and uniform physical properties, while a pH test of 7.32 supported suitability for oral delivery. Conclusion: Based on these characterization results, nanoencapsulation of cinnamon bark extract using chitosan alginate polymer shows significant potential as a drug delivery system for cervical cancer therapy