CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis
CXCL7 contributes to the bone erosion in RA by enhancing RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathways. CXCL7 could potentially be targeted for therapeutic interventions in RA.
Authors
- Lin Sun (ORCID: https://orcid.org/0000-0001-7496-7685)
- Jinxia Zhao (ORCID: https://orcid.org/0000-0002-8225-0921)
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-2151-9824)
- Changhong Li (ORCID: https://orcid.org/0000-0001-9067-4110)
- Zhuo An
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s13075-025-03502-1
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Third Hospital