<scp>H<sub>2</sub>S</scp> Donor <scp>SPRC</scp> Ameliorates Ischemic Stroke by Upregulating <scp>CD24</scp>
CD24 could be a potential target of inhibiting neuroinflammation. SPRC reduces inflammation in ischemic stroke by regulating the CD24/Iκ-Bα/NF-κB inflammatory signaling pathway and improves the migration ability of M2 microglia via CD24/Src/Fak/Pyk2 signaling pathway, which further alleviates the inflammatory response at the lesion.
Authors
- Yicheng Mao
- Pinwen Wu
- Jiejia Li
- Qing Zhu (ORCID: https://orcid.org/0000-0002-9411-9517)
- Haiyan Xi (ORCID: https://orcid.org/0000-0002-9105-229X)
- Qixiu Li
- Yi Zhun Zhu (ORCID: https://orcid.org/0000-0001-7700-8041)
- Sha Li (ORCID: https://orcid.org/0000-0001-8256-1263)
- Chenye Wang (ORCID: https://orcid.org/0000-0002-1231-2672)
Institutions
- Macau University of Science and Technology (MO)
- Nantong University (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Nantong University
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70243
- Citations
- 4
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 4.45
Funders
- Science and Technology Commission of Shanghai Municipality