Optimizing Prognostic Assessment in High‐Risk Head and Neck Squamous Cell Carcinomas: The Impact of Tumor Budding and a Novel Histomorphological Scoring System
This study reveals the potential prognostic value of TB and PDC in high-risk HNSCC, which may offer a practical and cost-effective alternative to traditional markers. Our proposed practicable and straightforward employable scoring system significantly correlates with OS, suggesting its potential benefit in clinical practice. These findings advocate for further validation to enhance prognostic accuracy and guide treatment strategies in HNSCC.
Authors
- Felix Braun (ORCID: https://orcid.org/0000-0002-5296-2020)
- Silke Wemmert
- Maximilian Linxweiler (ORCID: https://orcid.org/0000-0002-5028-9282)
- Jan Philipp Kühn (ORCID: https://orcid.org/0000-0001-5692-8543)
- Sigrun Smola (ORCID: https://orcid.org/0000-0003-3289-6545)
- Sandrina Körner (ORCID: https://orcid.org/0000-0002-6435-2940)
- Moritz Knebel
- Martin Ertz
- Luc G.T. Morris (ORCID: https://orcid.org/0000-0002-4417-2280)
- Gilbert Georg Klamminger
- Mathias Wagner
- Bernhard Schick
- Lukas Brust
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Helmholtz Centre for Infection Research (DE)
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Saarland University (DE)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/cam4.70685
- Citations
- 2
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universität des Saarlandes