Mechanistic insights of lenvatinib: enhancing cisplatin sensitivity, inducing apoptosis, and suppressing metastasis in bladder cancer cells through EGFR/ERK/P38/NF-κB signaling inactivation
In conclusion, the induction of apoptosis and the inhibition of EGFR/ERK/P38/NF-κB signaling are correlated with lenvatinib's ability to hinder tumor progression and enhance the cytotoxic effects of cisplatin in bladder cancer. These findings underscore the potential of lenvatinib as a therapeutic option for bladder cancer, either as a standalone treatment or in combination with cisplatin.
Authors
- Fei‐Ting Hsu (ORCID: https://orcid.org/0000-0002-2153-340X)
- Che-Jui Yang
- Kai‐Wen Hsu (ORCID: https://orcid.org/0000-0002-9736-8869)
- Chih‐Hung Chiang (ORCID: https://orcid.org/0000-0002-1224-6791)
- I‐Tsang Chiang (ORCID: https://orcid.org/0000-0003-1393-9335)
- Jr-Di Yang (ORCID: https://orcid.org/0000-0002-1483-7106)
- Weilin Liu (ORCID: https://orcid.org/0000-0003-2956-6393)
- Fang-Yu Chang
Institutions
- Ministry of Health and Welfare (KR)
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- National Central University (TW)
- National Yang Ming University Hospital (TW)
- Chang Bing Show Chwan Memorial Hospital (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
- Central Taiwan University of Science and Technology (TW)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12935-024-03597-7
- Citations
- 6
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Shanghai Educational Development Foundation
- Ministry of Education, India
- China Medical University
- Chang Bing Show Chwan Memorial Hospital