Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer
This study underscores the significance of molecular biomarkers in predicting clinical outcomes to CDK4/6i. Tumor-infiltration CD8<sup>+</sup> T and NK cells may also serve as baseline predictors. These insights pave the way for optimizing therapeutic strategies based on microenvironment-specific changes, providing a personalized and effective approach for managing HR+/HER2- mBC and improving patient outcomes.
Authors
- Senthil Damodaran (ORCID: https://orcid.org/0000-0002-2470-0891)
- Linjie Luo (ORCID: https://orcid.org/0000-0002-2365-0327)
- Akshara Singareeka Raghavendra (ORCID: https://orcid.org/0000-0002-6425-4400)
- Sofia Mastoraki (ORCID: https://orcid.org/0000-0001-8140-6106)
- Kelly K. Hunt (ORCID: https://orcid.org/0000-0001-9156-8723)
- Peng Yang (ORCID: https://orcid.org/0000-0002-9724-7936)
- Nicole M. Kettner (ORCID: https://orcid.org/0000-0003-2043-4407)
- Khandan Keyomarsi (ORCID: https://orcid.org/0000-0002-5440-0849)
- Yan Wang (ORCID: https://orcid.org/0000-0001-9566-8975)
- Xiayu Rao (ORCID: https://orcid.org/0000-0001-5245-7449)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Ziyi Li (ORCID: https://orcid.org/0000-0001-8359-0533)
- Debasish Tripathy
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Rice University (US)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12943-025-02226-9
- Citations
- 30
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 45.55