Shenfuyixin Granules enhance mitochondrial autophagy after myocardial infarction by regulating protein deacetylation via the SIRT3/FOXO1 signaling axis
This study demonstrates that SFYX exerts cardioprotective effects against HF through the deacetylation-regulated activation of SIRT3/FOXO1 signaling-mediated mitophagy and apoptosis. These findings indicate that SFYX represents a promising therapeutic candidate for the treatment of HF.
Authors
- Yanze Liu (ORCID: https://orcid.org/0000-0001-8858-8571)
- Mingjun Zhu (ORCID: https://orcid.org/0000-0001-7646-6577)
- Qifei Zhao (ORCID: https://orcid.org/0000-0002-9808-5684)
- Jiale Yun
- Jingjing Wei (ORCID: https://orcid.org/0000-0002-3352-5191)
- Bin Wang (ORCID: https://orcid.org/0000-0002-1735-9285)
- Xinlu Wang (ORCID: https://orcid.org/0000-0002-2875-4125)
- Shanshan Nie
- Yongxia Wang (ORCID: https://orcid.org/0000-0002-8733-3822)
- W. Han (ORCID: https://orcid.org/0000-0002-7814-2098)
- Lanxin Li (ORCID: https://orcid.org/0000-0003-0576-001X)
- Ruipeng Wu (ORCID: https://orcid.org/0000-0003-0004-1112)
Institutions
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-16
- DOI
- https://doi.org/10.1016/j.phymed.2025.156503
- Citations
- 10
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 12.24