The Interaction and Mediation of Physical Activity of Body Mass Index with Cardiovascular Disease: Evidence from NHANES and MR Analysis
PA modified the association of BMI with CVD, suggesting that sufficient PA is needed to lower the impact of high BMI on CVD risk. Moreover, we found that PA served as a causal influence on the association of BMI with CVD, indicating that higher BMI led to a lower level of PA, which in turn increased the risk of CVD.
Authors
- Zhiqing He (ORCID: https://orcid.org/0000-0001-8363-1286)
- Tengfei Zhang (ORCID: https://orcid.org/0000-0002-7160-4827)
- Shuo Han (ORCID: https://orcid.org/0000-0003-4542-6358)
- Junyu Wang (ORCID: https://orcid.org/0009-0009-3981-5884)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-7466-3945)
- Faming Zhang (ORCID: https://orcid.org/0000-0003-4157-1144)
- Chu Wang (ORCID: https://orcid.org/0000-0001-5360-747X)
- Danfeng Zhang (ORCID: https://orcid.org/0000-0003-2444-9227)
Institutions
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1249/mss.0000000000003668
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00