Trichosporon asahii and Candida guilliermondii as a Source of Orbital Infection in an Immunocompromised Individual

A 47-year-old male with a history of immunosuppression and recent intensive care unit admission presented with progressive orbital swelling and pain. Blood cultures grew <i>Trichosporon asahii</i> and <i>Candida guilliermondii</i>, with matching positive cultures from peripheral and central venous samples. Given his fungemia and worsening orbital involvement, induction therapy with amphotericin B and isavuconazole was initiated. Within weeks, clinical improvement was noted, prompting a transition to long-term consolidation therapy with oral posaconazole and isavuconazole. At follow-up, the patient demonstrated sustained clinical stability with no recurrence of infection. Orbital involvement from fungemia due to <i>T. asahii</i> and <i>C. guilliermondii</i> is rare, and management requires early recognition, aggressive antifungal therapy, and careful monitoring.