An LNP-mRNA vaccine modulates innate cell trafficking and promotes polyfunctional Th1 CD4+ T cell responses to enhance BCG-induced protective immunity against Mycobacterium tuberculosis
This work was supported by the NHMRC Centre of Research Excellence in Tuberculosis Control to JAT and WJB (APP1153493), and MRFF mRNA Clinical Trial Enabling Infrastructure grant to CWP and HAW (MRFCTI000006).
Authors
- Hareth Al-Wassiti (ORCID: https://orcid.org/0000-0002-8840-8654)
- Megan Steain (ORCID: https://orcid.org/0000-0002-7631-4204)
- Claudio Counoupas (ORCID: https://orcid.org/0000-0002-0283-4004)
- Hannah Lukeman
- Trixie Wang
- Colin W. Pouton (ORCID: https://orcid.org/0000-0003-0224-3308)
- James A. Triccas (ORCID: https://orcid.org/0000-0003-3730-2339)
- Leonard Whye Kit Lim (ORCID: https://orcid.org/0000-0003-4079-9630)
- Warwick J. Britton (ORCID: https://orcid.org/0000-0001-6721-9646)
- Stewart A. Fabb (ORCID: https://orcid.org/0000-0002-8887-7661)
Institutions
- The University of Sydney (AU)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1016/j.ebiom.2025.105599
- Citations
- 12
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 16.75
Funders
- National Health and Medical Research Council