US Geriatric Assessment Practices for Older Adults Undergoing Hematopoietic Cell Transplantation or Chimeric Antigen Receptor T Cell Therapy: An American Society for Transplantation and Cellular Therapy Physician Survey from the Aging Special Interes
Geriatric assessment (GA) may identify vulnerabilities and promote risk-stratification in older adults predisposed to toxicities after autologous (auto), allogeneic (allo) hematopoietic cell transplantation (HCT) and chimeric antigen T-cell therapies (CAR T). With increased utilization cellular therapies for older adults the American Society for Transplantation and Cellular Therapy (ASTCT) Committee on Practice Guidelines and its Special Interest Group for Aging (SIG) conducted an online cross-sectional survey between April 2023 and August 2023 to determine transplantation and cellular therapy physicians' practice patterns regarding GA in older patients receiving HCT and CAR T-cell therapies. E-mail surveys were sent to 1168 ASTCT physician members and only 96 (8.2%) respondents completed the survey. Most (86%) were affiliated with university/teaching centers and 70% had a combined HCT and cellular therapy practice. More than 50% of respondents were interested in pursuing GA but 68% described barriers. The top two recognized barriers to GA were lack of time (96%) and clinical support staff (90%). Despite interest, only 15% respondents reported to know the domains of GA 'well'. Among those using GA, the minimum age used for routine GA was 65 years for allo-HCT and CAR T in over 91% respondents. Taken together, we recommend the HCT community leadership and GA experts combine efforts to address the gap in GA uptake and implementation.
Authors
- Shatha Farhan (ORCID: https://orcid.org/0000-0002-5723-7442)
- Mehdi Hamadani (ORCID: https://orcid.org/0000-0001-5372-510X)
- Mohamed L. Sorror (ORCID: https://orcid.org/0000-0001-5260-1981)
- Mohamed A. Kharfan‐Dabaja (ORCID: https://orcid.org/0000-0001-7394-5185)
- Paul A. Carpenter (ORCID: https://orcid.org/0000-0002-5021-0714)
- Ashley Elizabeth Rosko (ORCID: https://orcid.org/0000-0001-5875-3214)
- Richard J. Lin (ORCID: https://orcid.org/0000-0002-0834-7880)
- Hemant S. Murthy (ORCID: https://orcid.org/0000-0003-4534-4248)
- Yoshihiro Inamoto (ORCID: https://orcid.org/0000-0003-4881-0427)
- Marco Ruiz
- Reena Jayani (ORCID: https://orcid.org/0000-0002-5291-5945)
- Zachariah DeFilipp (ORCID: https://orcid.org/0000-0002-7994-8974)
- Taha Al‐Juhaishi
- Parastoo Bahrami Dahi (ORCID: https://orcid.org/0000-0002-0794-3226)
- Sarah Wall (ORCID: https://orcid.org/0000-0002-8845-1046)
- Betty K. Hamilton (ORCID: https://orcid.org/0000-0003-1252-6539)
- Vijaya Raj Bhatt (ORCID: https://orcid.org/0000-0003-2513-0533)
- Gabrielle Meyers (ORCID: https://orcid.org/0000-0001-7821-8745)
- Andrew Artz (ORCID: https://orcid.org/0000-0003-0803-9607)
- Pashna N. Munshi (ORCID: https://orcid.org/0000-0002-8079-9443)
- Anthony D. Sung (ORCID: https://orcid.org/0000-0003-3765-641X)
- Shannon R. McCurdy (ORCID: https://orcid.org/0000-0002-2813-6781)
- Rebecca L. Olin (ORCID: https://orcid.org/0000-0002-5060-0384)
- Nora Chokr (ORCID: https://orcid.org/0000-0002-2275-2508)
- Manuel Ricardo Espinoza-Gutarra (ORCID: https://orcid.org/0000-0002-7906-8782)
- Asmita Mishra (ORCID: https://orcid.org/0000-0003-3065-4294)
- Lohith Gowda (ORCID: https://orcid.org/0009-0001-1726-9749)
- Julie Baker
- Mariam Nawas
Institutions
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- Henry Ford Health System (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Wayne State University (US)
- Medical College of Wisconsin (US)
- Cornell University (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- University of Alabama at Birmingham (US)
- University of Chicago Medical Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Presbyterian Hospital (US)
- City of Hope (US)
- University of Kansas Medical Center (US)
- Oklahoma State University Oklahoma City (US)
- Mayo Clinic in Florida (US)
- Miami Transplant Institute (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- OU Health Stephenson Cancer Center
- University of Oklahoma Health Sciences Center (US)
- The Ohio State University (US)
- University of Nebraska Medical Center (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Transplantation and Cellular Therapy
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1016/j.jtct.2025.02.014
- Citations
- 1
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 1.22