Gender difference and BMDL exploration of developmental immunotoxicity induced by early-life low-dose exposure to 4-nonylphenol in Wistar rats
Early-life exposure to 4-NP has been shown to induce gender-specific developmental immunotoxicity in rats, with female pups exhibiting greater sensitivity. And developmental immunotoxicity may serve as a more sensitive indicator for the risk assessment of 4-NP. Th17/Treg balance may be interrupted through JNK/STAT pathway by 4-NP exposure, which needs to be further investigated.
Authors
- Zhenchao Jia
- Jiuming Yan
- Qilin Wei (ORCID: https://orcid.org/0000-0002-1604-0600)
- Jinyao Chen (ORCID: https://orcid.org/0000-0003-0519-4935)
- Jinghua Xie
- Xiaoya Wang (ORCID: https://orcid.org/0009-0006-4154-3003)
- Liang Wang (ORCID: https://orcid.org/0009-0009-7673-7272)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Mianyang Third People's Hospital (CN)
Publication Details
- Journal
- Toxicology
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1016/j.tox.2025.154085
- Citations
- 2
- Primary Topic
- Immunotoxicology and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China