Neferine attenuates hypertensive cardiomyocyte apoptosis and modulates key signaling pathways: An in vivo and in vitro study
Neferine treatment effectively mitigated hypertensive cardiomyocyte apoptosis and attenuated the abnormal activation of multiple signaling pathways, including the PI3K/Akt, MAPK, and HIF-1 pathways.
Authors
- Lingqi Chen
- Dawei Lian
- Jinkong Wu
- Qiurong Xie (ORCID: https://orcid.org/0000-0003-0033-2163)
- Meizhu Wu (ORCID: https://orcid.org/0000-0003-2010-8644)
- Jun Peng (ORCID: https://orcid.org/0000-0002-1641-6647)
- Aling Shen (ORCID: https://orcid.org/0000-0002-5081-3523)
- Zhi Guo
- Hong Chen (ORCID: https://orcid.org/0000-0003-4912-6328)
- Guosheng Lin
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177393
- Citations
- 2
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China