Transarterial chemoembolisation with irinotecan (irinotecan-TACE) as salvage or post-inductive therapy for colorectal cancer liver metastases: effectiveness results from the CIREL study
The results from the largest, pan-European, real-life study on irinotecan-TACE for CRLMs show a comparably long median OS when used as salvage therapy and promising HPFS when used with systemic therapy or thermal ablation as post-inductive/consolidation therapy. With its potential to maintain HRQoL, irinotecan-TACE could be further integrated into systemic treatment pathways.
Authors
- Thierry de Baère (ORCID: https://orcid.org/0000-0002-4556-7663)
- Dirk Arnold (ORCID: https://orcid.org/0000-0002-5325-8182)
- Philippe L. Pereira (ORCID: https://orcid.org/0000-0002-9913-2120)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Bleranda Zeka
- Thomas Helmberger (ORCID: https://orcid.org/0000-0001-8814-8154)
- Roberto Iezzi (ORCID: https://orcid.org/0000-0002-2791-481X)
- Olivier Pellerin (ORCID: https://orcid.org/0000-0003-2493-6607)
- Hans Prenen (ORCID: https://orcid.org/0000-0001-8802-7352)
- Nathalie Kaufmann (ORCID: https://orcid.org/0000-0002-4823-6923)
- Stavros Spiliοpoulos (ORCID: https://orcid.org/0000-0003-1860-0568)
- Fernando Gómez (ORCID: https://orcid.org/0000-0003-0944-9819)
- Geert Maleux (ORCID: https://orcid.org/0000-0003-0598-0258)
- Bruno Sangro (ORCID: https://orcid.org/0000-0002-4177-6417)
- A. Gjoreski
Institutions
- Délégation Paris 5 (FR)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- Universitair Ziekenhuis Leuven (BE)
- Institut Gustave Roussy (FR)
- Agostino Gemelli University Polyclinic (IT)
- München Klinik Bogenhausen (DE)
- Asklepios Klinik Altona (DE)
- Antwerp University Hospital (BE)
- Hôpital Européen Georges-Pompidou (FR)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Clinica Universidad de Navarra (ES)
- PHI University Psychiatric Clinic - Skopje (MK)
- SLK-Kliniken Heilbronn (DE)
- Cardiovascular and Interventional Radiological Society of Europe (AT)
- Catholic University of America (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1016/j.esmoop.2025.104292
- Citations
- 4
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.29