Investigating the causal relationship between the gut microbiome and rheumatoid arthritis: mediating effects of immune cells
This research clarifies the intricate causal links between gut microbiota and RA, emphasizing the crucial mediating function of immune cells in this mechanism. These findings not only enhance our understanding of the pathogenesis of RA but also provide new perspectives and potential intervention targets for future prevention and treatment strategies. Future research should further investigate the specific mechanisms underlying the interactions among gut microbiota, immune cells, and RA, while considering the validation of these findings across diverse populations.
Authors
- Fang Tang (ORCID: https://orcid.org/0009-0008-9641-676X)
- Zhengzhen Wang
- Qianwei Lu
- Wukai Ma (ORCID: https://orcid.org/0000-0002-7742-7171)
- Yú Chen (ORCID: https://orcid.org/0000-0003-2491-3974)
- Xueming Yao (ORCID: https://orcid.org/0000-0001-6964-1509)
- Weiya Lan
- Zong Jiang
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12967-025-06206-x
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China
- Guizhou University
- Science and Technology Program of Guizhou Province