Mcl-1 downregulation enhances BCG treatment efficacy in bladder cancer by promoting macrophage polarization
Down-regulation of Mcl-1 promotes the polarization of macrophages towards the M1 type through activation of the ASK1/MKK7/JNK signaling pathway. This enhances intercellular communication and improves the efficacy of BCG in bladder cancer treatment.
Authors
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7946-9810)
- Shengpeng Wang (ORCID: https://orcid.org/0000-0002-9030-1821)
- Xinmin Wang (ORCID: https://orcid.org/0000-0002-5817-1502)
- Ziyi Wu (ORCID: https://orcid.org/0000-0001-6207-381X)
- Le Zhang (ORCID: https://orcid.org/0000-0002-3708-1727)
- Chen Li (ORCID: https://orcid.org/0000-0003-2261-2369)
- Ruihan Ge (ORCID: https://orcid.org/0000-0002-7611-769X)
- Caixia Tan
- Haotian Cui
Institutions
- Shihezi University (CN)
- First Affiliated Hospital of Shihezi University Medical College (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12935-025-03676-3
- Citations
- 10
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 20.06