The proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases
Our findings highlight the dependency of DMG on methyl-signaling pathways, particularly involving METTL13, which regulates EEF1A1 protein methylation and oncoprotein synthesis. Targeting the non-histone methyltransferases offers a promising therapeutic strategy for DMG. This study underscores the potential of post-translational modifications, specifically methyl-signaling pathways, as novel therapeutic targets for DMG and possibly other currently incurable cancers.
Authors
- Lauren Phillips (ORCID: https://orcid.org/0000-0002-4309-2465)
- Sanja Pajovic
- Sabrina Zhu
- Mark Nitz (ORCID: https://orcid.org/0000-0001-8078-2265)
- Stefanie-Grace Sbergio
- Robert Siddaway (ORCID: https://orcid.org/0000-0003-2013-9467)
- Cynthia Hawkins (ORCID: https://orcid.org/0000-0003-2618-4402)
- Yong Jia Bu (ORCID: https://orcid.org/0000-0001-9390-0494)
- Arun Kumaran Anguraj Vadivel (ORCID: https://orcid.org/0000-0002-6384-6316)
- Olivera Matic
Institutions
- University of New Brunswick (CA)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Canada Research Chairs (CA)
- Brain Tumour Research (GB)
- SickKids Foundation (CA)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1093/neuonc/noaf033
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.03