Identifying insulin-responsive circRNAs in chicken pectoralis
This study reveals the dynamic and breed-specific roles of circRNAs, particularly circINSR, in avian skeletal muscle's response to insulin. The distinct regulation of circINSR and INSR under various metabolic conditions suggests a complex regulatory mechanism. These findings provide novel insights into the molecular basis of insulin signaling in avian species and highlight the potential of circRNAs as biomarkers for metabolic regulation.
Authors
- Xiangli Zhang (ORCID: https://orcid.org/0000-0002-5790-1147)
- Xuemeng Si
- Pengna Luo
- Yanqun Huang (ORCID: https://orcid.org/0000-0002-4427-2767)
- Binghao Shao
- Sen Ma (ORCID: https://orcid.org/0000-0002-9857-0858)
- Huaiyong Zhang (ORCID: https://orcid.org/0000-0002-1490-8541)
- Pengfei Du (ORCID: https://orcid.org/0000-0002-4650-0583)
- Ziyang Wang (ORCID: https://orcid.org/0000-0001-6130-6212)
- Wen Chen (ORCID: https://orcid.org/0000-0001-8536-3174)
Institutions
- Henan Agricultural University (CN)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-15
- DOI
- https://doi.org/10.1186/s12864-025-11347-w
- Citations
- 4
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China