Prospects for the application of nanotechnology in the development of antitumor drugs
Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, evaluate their clinical effectiveness, and identify promising directions in nanotechnology development for cancer therapy. Material and methods. Analysis of current scientific publications on the development and application of various types of nanoparticles in oncology, including clinical trial data and approved drugs. Results. The physicochemical properties and therapeutic potential of liposomal, polymeric, and metallic nanoparticles are examined. Analysis of clinically approved nanomedicines and promising developments is presented. Ethical and regulatory aspects of nanotechnology applications in oncology are discussed. Conclusion. Nanotechnology demonstrates significant potential in improving cancer therapy effectiveness. The development of “smart” nanomaterials, integration with CRISPR technologies, and creation of multifunctional nanosystems represent the most promising research directions.
Authors
- Kristina Ilina
- M. A. Ananyan (ORCID: https://orcid.org/0009-0008-6263-3790)
- P. Seliverstov (ORCID: https://orcid.org/0000-0001-5623-4226)
- S. S. Marchenko (ORCID: https://orcid.org/0000-0003-3084-176X)
- Mikhail A. Stepanov (ORCID: https://orcid.org/0000-0002-1872-9487)
- E.A. Voznesenskaya
- K.Yu. Lyapustin
Institutions
- St Petersburg University (RU)
- Sechenov University (RU)
- S. M. Kirov Military Medical Academy (RU)
- Tver State Medical University (RU)
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Molekulyarnaya Meditsina (Molecular medicine)
- Published
- 2025-02-15
- DOI
- https://doi.org/10.29296/24999490-2025-01-01
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00