Isolated Urticarial Rash in the Clinical Spectrum of HA20
A20 is a deubiquinating enzyme acting as a negative regulator in the nuclear factor κB (NF-κB) pathway.<sup>1</sup> It is encoded by the tumor necrosis factor (TNF)-alpha induced protein 3 (<i>TNFAIP3</i>) gene and consists of 2 domains: an amino-terminal ovarian tumor domain carrying the deubiquitinating activity, and a carboxy-terminal zinc finger domain, which has ubiquitin ligase and polyubiquitin-binding ability.<sup>1</sup>
Authors
- Alexandra Pennal
- Maria Vincenza Mastrolia (ORCID: https://orcid.org/0000-0002-9784-3543)
- Lucy Duan (ORCID: https://orcid.org/0000-0002-0560-583X)
- Dilan Dissanayake (ORCID: https://orcid.org/0000-0003-4270-7015)
- Ronald M. Laxer
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Alexandra Hospital (SG)
- Hospital for Sick Children (CA)
- Meyer Children's Hospital (IT)
- SickKids Foundation (CA)
- University of Florence (IT)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2025-02-15
- DOI
- https://doi.org/10.3899/jrheum.2024-1134
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00