Intake of Trans‐Fat Diet With Prenatal Bisphenol A Exposure Induce Global <scp>DNA</scp> Methylation in Rats Offspring
This study underscores the potential impact of prenatal BPA exposure and postnatal TFD intake on epigenetic regulation, as evidenced by global DNA hypermethylation, despite no observable changes in PPAR-γ protein expression. These findings suggest that early-life environmental exposures may predispose individuals to metabolic disruptions, including diabetes and obesity, in adulthood or future generations.
Authors
- Hala Abulehia (ORCID: https://orcid.org/0000-0002-6562-7651)
- Siti Hamimah Sheikh Abdul Kadir (ORCID: https://orcid.org/0000-0002-1671-4839)
- Noor Shafina Mohd Nor (ORCID: https://orcid.org/0000-0003-1057-7850)
Institutions
- Hospital Sungai Buloh (MY)
- Universiti Teknologi MARA (MY)
Publication Details
- Journal
- Birth Defects Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/bdr2.2450
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00